Exonate are always keen to hear from highly experienced individuals in screening science, cell biology, biochemistry and pharmacology. We currently have the following opportunities.
Senior scientist – Pharmacology (ref. EX008)
Exonate Ltd is a fast growing, dynamic pharmaceutical company focusing on translating discoveries in alternative splicing technology to therapeutics.
Following a series of major investments, we have an opportunity for a senior scientist to enable progression of an expanding drug project portfolio in the Biology team of our Nottingham laboratories. The role of the Exonate Biology Department is to provide in vitro and in vivo pharmacology support to discovery teams focused on identifying small molecules for the treatment of diseases of the back of the eye and other indications. The Biology Department is an integrated part of discovery programmes, supporting the identification of lead molecules through in vivo model screening and the characterization of the mechanism of action of promising development candidates.
This is a “hands-on” scientific and technical role and the successful candidate will be expected to remain active in the laboratory and “lead from the bench.” Reporting to the Head of Biology, the candidate will have responsibility for the design, planning, execution and interpretation of in vivo studies focused on identifying candidate molecules within the area of ophthalmology. The candidate will drive scientific excellence and lead by example in the lab by demonstrating best practices in the development, implementation and execution of in vivo models. The post-holder will be expected to communicate data to multidisciplinary teams. The candidate must have strong written and oral communication skills, be self-motivated, innovative, a team player and must be able to work independently.
- Independently design, plan, execute and interpret complex in vivo studies focused on identifying small molecules within the area of ophthalmology
- Formulation of small molecules for in vivo studies.
- Evaluation of endpoints from in vivo studies via techniques such as qPCR, IHC, ELISA, Mass Spectrometry and Western blots.
- Plan, execute and interpret pharmacokinetic/pharmacodynamic studies.
- Data presentation to multidisciplinary discovery teams.
- Preparation of technical reports.
- Identification of risks within function and development of contingencies plans to mitigate risk.
PhD in cell biology, pharmacology or relevant scientific discipline; minimum 3 years of work experience or relevant academic experience. MSc degree in a relevant scientific discipline with at least 6 years work experience.
Requirements & Education A broad understanding of cellular and molecular pharmacology concepts within the ophthalmology/angiogenesis field is essential. Previous experience in the biopharmaceutical industry is required with a successful record of project impact.
- Experience with small animal imaging is highly desired
- Experience in ophthalmology and animal models of disease and methodologies used to study ocular physiology.
- In vivo skills include animal handling, dosing of small molecules, sample preparation, small animal surgery, imaging modalities and experience with more complex transgenic and knockout models.
- Proficiency in laboratory bench skills such as ELISAs, Western blots, qPCR, Flow cytometry, and/or histology is required.
- Experience in ex vivo ocular permeability assays is a plus
- Proven track record of good experimental design, in-depth data analysis and interpretation based on strong scientific rationale
- Detail oriented and able to problem solve and offer potential solutions
- Excellent written and oral communication skills
- Works independently or as part of a team in a fast-paced environment
- Computer skills: Advanced knowledge of Excel, Word, Powerpoint and Graphpad prism
If you are interested and would like to be considered for the post, please send a covering letter and your CV outlining your suitability for this role to HR@exonate.com
Please ensure you quote job reference EX008
NO AGENCIES PLEASE